Malcolm Brogdon hit a 3-pointer with 0.4 seconds to play to lift Virginia over No. 18 Pitt, 48-45, before a crowd of 12,508 at the Petersen Events Center.
The Panthers (18-4, 6-3 in the ACC) had a chance to take a lead the possession before Brogdon hit the game-winner but James Robinson missed an open look at a 3-pointer and Jamel Artis, who got the offensive rebound, missed a putback.
It was that kind of day for the Panthers, who lost for the second time in a row at home and fell into a third-place tie with Duke in the ACC, as they made only 15-of-47 field goal attempts (31.9 percent) and only 11-of-19 (57.9 percent) from the free throw line.
The game was close the entire way as both teams play with a very similar philosophy of hard-nosed defense and patient, deliberate offense making possessions and points at a premium.
Pitt looked like it might have hit the shot to turn the game in its favor, though, with 6:52 to play when Cameron Wright hit a turn around, bank-shot 3-pointer as the shot-clock expired to give the Panthers a 44-41 lead.
But the Panthers scored only one more point the entire game and Joe Harris tied the game at 45-45 with 3:12 to play with a free throw.
Neither team scored again until Brogdon, who led Virginia (17-5, 8-1) with 16 points and 5 rebounds, hit the big shot to win the game.
Artis led the Panthers with 11 points and 7 rebounds and Lamar Patterson added 10 points, though he was 3-of-14 from the field.
Paul Zeise: email@example.com, 412-263-1720 or on Twitter @paulzeise.