DURHAM, N.C. -- Pitt protected the ball and passed it well, but making shots was a different story.
The Panthers shot just 30 percent from the floor in their 111-67 ACC loss Sunday at No. 3 Duke in Cameron Indoor Stadium.
Pitt hit 6 of 25 3-point attempts, many of which were open shots against the Blue Devils' matchup zone defense.
"I thought they were really good looks," Pitt guard Brianna Kiesel said. "It's just knocking them down. We struggled a little bit at Notre Dame, and we struggled again this game. But just building off that, if we get those looks, those are going to start falling for us."
Kiesel scored 19 points to lead the Panthers (9-11, 1-5). Asia Logan added 17 points and Loliya Briggs had 12 points for Pitt.
For Duke (20-1, 7-0), Tricia Liston scored 23 points and became the program's all-time leader in career 3-pointers.
Elizabeth Williams added 20 points for the Blue Devils, who shot a season-best 60 percent from the floor and never trailed.
Haley Peters had 16 points and 12 rebounds for Duke. Amber Henson added a career-high 13 points, Oderah Chidom had 12 and Alexis Jones had 11 for the Blue Devils.
"Duke is very talented," Pitt coach Suzie McConnell-Serio said. "If you try to take away an inside presence, they kill you from outside. They're just so balanced and have so many weapons. It was a tough matchup for us across the board. We were undersized, overmatched."
Liston led the way, making 8 of 10 shots from the floor and 3 of 4 3-point attempts.
Her record-breaking 223rd 3-pointer came on a jumper from the left wing with 13:24 left in the first half. The shot gave the Blue Devils a 20-12 lead and started a 15-2 run that helped them take control of the game.
Liston's record previously was held by Abby Waner.
"It's kind of irrelevant when you're playing," Liston said. "But off the court, it's a great accomplishment and something I'm very proud of. But I try not to think about it too much when I'm playing, if at all."
Duke reached 20 wins for the 17th consecutive season, the third longest active streak in Division I. The Blue Devils also extended their ACC-record home winning streak against conference foes to 42 games and posted their 130th consecutive home victory against unranked opponents.
Duke led, 55-29, after a first half that featured plenty of highlights in addition to Liston's record-breaking 3-pointer.
After Pitt cut Duke's lead to 34-22 lead with eight minutes remaining, the Blue Devils delivered a 17-2 spurt to pull away.
Jones had the crowd oohing, aahing in the span of a few seconds with a series of behind-the-back dribbles followed by a no-look feed to Williams for a layup. Later in that run, Henson made the first 3-pointer of her career.
Duke made 17 of its first 22 field-goal attempts en route to shooting 66 percent from the floor in the first half. The Panthers, meanwhile, were just 8 for 37. Pitt came up with 12 offensive rebounds in the first half, but those only yielded seven points.