Pitt's Jim Negrych and Billy Muldowney were selected by the Pirates and Chicago Cubs, respectively, on the first day of the amateur draft.
The Pirates took Negrych, a second baseman, in the sixth round. He's the first Pitt player drafted by the Pirates since Ken Macha in 1972.
"I was able to take some swings at PNC Park and it really is the best ballpark in the country," Negrych said. "I'm thrilled to be drafted by the Pirates."
Negrych, from Buffalo, N.Y., hit .396 this season and ranks in the top 10 in nearly every Pitt offensive category.
Muldowney, from West Chester, Pa., was 5-4 with a 3.16 earned run average this season. He struck out 99 in 822/3 innings.
This is the first year two Panthers were picked within the first eight rounds.
Pitcher Brian Omogrosso, from Blackhawk High School and Indiana State University, was drafted by the Chicago White Sox in the sixth round.
Erik Arnesen, a right-handed pitcher from Grove City College, was a 17th-round selection of the Washington Nationals.
Nathan Nery, a Moon High School graduate and a left-handed pitcher at Stetson University in Florida, was an 18th-round pick by the Baltimore Orioles.