Advanced breast cancer edges up in younger women

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CHICAGO -- Advanced breast cancer has increased slightly among young women, a 34-year analysis suggests. The disease is still uncommon among women younger than 40, and the small change has experts scratching their heads about possible reasons.

The results are potentially worrisome because young women's tumors tend to be more aggressive than older women's, and they are much less likely to get routine screening for the disease.

Still, that does not explain why there would be an increase in advanced cases, and the researchers and other experts say more work is needed to find answers. It is likely that the increase has more than one cause, said Rebecca Johnson, the study's lead author, who is medical director of a teen and young adult cancer program at Seattle Children's Hospital. "The change might be due to some sort of modifiable risk factor, like a lifestyle change" or exposure to some sort of cancer-linked substance, she said.

Dr. Johnson said the results translate to about 250 advanced cases diagnosed in women younger than 40 in the mid-1970s versus more than 800 in 2009. During those years, the number of women nationwide in that age range went from about 22 million to closer to 30 million -- an increase that explains part of the study trend, "but definitely not all of it," Dr. Johnson said.

Other experts said women delaying pregnancy might be a factor, partly because getting pregnant at an older age might cause an already-growing tumor to spread more quickly in response to pregnancy hormones.

Obesity and having at least an alcoholic drink or two daily have both been linked with breast cancer, but research is inconclusive on other possible risk factors, including tobacco and chemicals in the environment. Whether any of these explains the slight increase in advanced disease in young women is unknown.

There was no increase in cancer at other stages in young women. There also was no increase in advanced disease among women older than 40.

Overall U.S. breast cancer rates have mostly fallen in more recent years, although there are signs that they may have plateaued.

Some 17 years ago, Dr. Johnson was diagnosed with early-stage breast cancer at age 27, and that influenced her career choice: to focus on the disease in younger women. "Young women and their doctors need to understand that it can happen in young women," and get checked if symptoms appear, said Dr. Johnson, now 44. "People shouldn't just watch and wait."

The authors reviewed a U.S. government database of cancer cases from 1976 to 2009. They found that among women aged 25 to 39, breast cancer that has spread to distant parts of the body -- advanced disease -- increased from between 1 and 2 cases per 100,000 women to about 3 cases per 100,000 during that time span. The study was published Tuesday in the Journal of the American Medical Association.

About 1 in 8 women will develop breast cancer in their lifetime, but only 1 in 173 will develop it by age 40. Risks increase with age, and certain gene variations can raise the odds.

Routine screening with mammograms is recommended for older women but not those younger than 40.

Len Lichtenfeld, the American Cancer Society's deputy chief medical officer, said the results support anecdotal reports, but that there is no reason to start screening all younger women, since breast cancer is still so uncommon for them. Dr. Lichtenfeld said the study "is solid and interesting and certainly does raise questions as to why this is being observed." One of the most likely reasons is probably related to changes in childbearing practices, he said, adding that the trend "is clearly something to be followed."

Ann Partridge, chair of the federal Centers for Disease Control and Prevention's advisory committee on breast cancer in young women, agreed, but said it is also possible that doctors look harder for advanced disease in younger women than in older patients. More research is needed to make sure the phenomenon is real, said Dr. Partridge, the breast cancer center director at Harvard-affiliated Dana-Farber Cancer Institute.

The study shouldn't cause alarm, she said. Still, Dr. Partridge said young women should be familiar with their breasts and see the doctor if they notice any lumps or other changes.



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