SAN FRANCISCO -- Sam LeCure, Mat Latos and three other relievers shut down San Francisco after Cincinnati lost ace Johnny Cueto in the first inning with a back injury, and the Reds were powered by home runs from Brandon Phillips and Jay Bruce to beat the Giants, 5-2, in Game 1 of the National League Division Series Saturday night at AT&T Park.
Phillips hit a two-run homer in the third and Bruce added a solo drive leading off the fourth as the Reds overcame losing Cueto, their 19-game winner.
San Francisco's Matt Cain allowed his first career postseason earned runs after going untouched during the Giants' improbable World Series season of 2010.
Reds skipper Dusty Baker earned an emotional win in his return for the playoffs 10 years after managing the Giants within six outs of a championship.
Cueto had the shortest postseason start in the majors in eight years when back spasms forced him to leave while pitching to the second batter of the game. He is day to day.
LeCure and scheduled Game 3 starter Latos held the Giants scoreless until Buster Posey's leadoff homer off Latos in the sixth cut Cincinnati's lead to 3-1.
Cincinnati had taken the lead on Phillips' one-out homer in the third that also scored Drew Stubbs. Bruce added a solo shot in the fourth.
The Giants added a second run in the ninth, when Aroldis Chapman threw a wild pitch, allowing Joaquin Arias to score from third.
Cain ended a run of 231/3 consecutive innings without an earned run that was the fifth-longest ever. It was also just the second time the past two seasons that Cain allowed two homers in a game at home with the other June 29 against Cincinnati.
The Reds got their first postseason win since 1995, having lost seven in a row since then in the 1995 NLCS to Atlanta and the division series two years ago to Philadelphia.
If Cueto's injury isn't serious, he could come back and take Latos' spot in the rotation in Game 3. If he can't come back, that could be a big blow to the Reds. His 2.58 ERA the past two seasons is third best in the majors and Cincinnati had to rely heavily on Latos and the bullpen in the opener of the best-of-five series.
The Reds ran to the NL Central title based on the health of their starting pitchers. None of their five starters got hurt all season and they only needed a sixth starter when Todd Redmond started the back end of a doubleheader in August against the Cubs.
Cueto struck out Angel Pagan to open the game but appeared as if he might have aggravated something when stopping mid-motion when Pagan called time out earlier in the at-bat.