NEW YORK -- With two starters out of the game and their legs growing weary, Pitt wanted no part of a second overtime against Duke last night. So when the Panthers were down two points and had the last possession they were going to go for the win.

Levance Fields came off a ball screen, faked like he was going toward the basket and then made a fade-away 3-pointer with four seconds left to give Pitt a 65-64 overtime victory against No. 6 Duke at Madison Square Garden.

"I knew we were down two, but I told them in the huddle that I was going for the win," said Fields, who led Pitt with 21 points. "With Mike down, I felt like we had to."

While the victory was sweet it might have come at a steep price. Senior guard Mike Cook went down with what appeared to be a serious knee injury with 4:28 remaining in the overtime. There was no preliminary report available after the game, but Cook was screaming in pain on the court and needed help to make it back to the locker room.

"This is a bittersweet victory," Pitt coach Jamie Dixon said. "We don't think this is good for Mike. Mike has been a leader for this team. Levance is his best friend. When he went down we said we were going to win this game for Mike, and his best friend hit that shot. I can't say enough about the heart of this team because we didn't play well early."

No. 11 Pitt (11-0) played so poorly that it was able to tie a school record for largest halftime deficit overcome in a game. The Panthers also came back from 12 down at halftime to beat Saint Francis, Pa., in 1983.

"This shows we have a lot of heart," said Pitt junior Sam Young, who had 17 points and seven rebounds. "We have a lot of pride. We weren't going to let a team do that to us."

Pitt was down by 16 at one point in the first half after uncharacteristically turning the ball over 13 times and playing out of sync on offense. Duke, meanwhile, shot 46 percent in the first half and raced to a 34-22 lead at the intermission.

The second half was a different story. Pitt seized control of the tempo and grabbed the momentum. Duke (10-1) shot just 30 percent in the second half under pressure from Pitt's swarming defense while the Panthers ratcheted up the offense with 43 points in the final 35 minutes.

"They took over that game with about 12 minutes to go in the second half with their persistent toughness," Duke coach Mike Krzyzewski said. "That's a trademark of their program. They wanted it more. In the second half they took over."

Duke had no answer for freshman DeJuan Blair inside. Blair was a monster in the middle, scoring 15 points and pulling down 20 rebounds before he fouled out with 1:36 remaining in the overtime period.

Blair continually outworked and outmuscled Duke's slender frontcourt players, pushing them aside like they were rag dolls. He was the big reason Pitt dominated the rebounding margin by 14 (53-39).

"DeJuan is a beast," Young said. "I have no words to describe him. It seems like he has magnetic hands. He's confident. He doesn't play like a freshman."

Pitt trailed, 43-33, with 12:47 left in regulation, but Duke only made five field goals the rest of the second half. The Panthers went on a 12-0 run to take their first lead since the opening minute after Young made two free throws with 5:27 remaining.

Neither team led by more than three the rest of the game. Young gave Pitt a 58-56 lead with 1:10 left, but Duke's Gerald Henderson answered that basket with 56 seconds left.

Cook missed a wide open 3-pointer with 20 seconds left in regulation. Henderson missed on a drive and Kyle Singler missed a tip at the buzzer.

Pitt took the lead, 62-59, after Fields made two free throws with 3:07 left in the overtime, but Duke came back to go ahead. After Henderson made one of two free throws, Demarcus Nelson scored on a 3-point play with 1:36 remaining to give the Blue Devils a 63-62 lead. Even worse for Pitt, Blair was the player who fouled him, and he had to go to the bench with five fouls.

Fields was called for an offensive foul driving to the basket with 34 seconds left. Singler made one of two free throws with 23 seconds remaining, leaving the door open for Pitt.

Dixon called a timeout after Pitt crossed half-court and set the play up. It's called five-up and is designed for Fields come off a screen. Young set the screen high, and Duke had to switch. Blue Devils forward David McClure had to guard Fields, and Pitt's 5-10 point guard, faked him out, then stepped back and made the winning shot.

"He does it every day in practice," Young said. "We're always trash talking to him, telling him to do it in a game. He proved he could do it when it counted."

Said Fields: "After it was over, I said to Sam, 'I just hit the game-winning shot.' When you're a kid you always dream about it. Now it's a dream come true."