CINCINNATI -- Jack Wilson hit a two-run homer and the Pittsburgh Pirates ended their season-opening six-game losing streak with a 5-3 win over the Cincinnati Reds at Great American Ball Park this afternoon.

Victor Santos (1-1) got his first win for the Pirates, who had not been 0-6 since 1974. He allowed two runs and four hits in 5 1-3 innings, striking out five. Four relievers followed, with Roberto Hernandez getting three outs for the save.

Dave Williams (0-1) lost to his former team in his first start for the Reds since they acquired him in December for first baseman Sean Casey. Williams gave up three runs -- two earned -- and five hits in six innings.

Pittsburgh's losing streak was two shy of the franchise record at the start of a season, set in 1955. The Pirates stopped Cincinnati's four-game winning streak.

Pittsburgh had runners in each of the first four innings but didn't score the game's first run until the fifth. Santos reached leading off on third baseman Edwin Encarnacion's throwing error, and Wilson followed one out later with his first home run of the season. It marked the Pirates' first lead since they were ahead of Milwaukee 1-0 after four innings on Wednesday.

Jose Castillo hit a sacrifice fly in the sixth after Jeromy Burnitz's leadoff double for a 3-0 advantage.

Santos, making his second start for Pittsburgh after being picked from Kansas City in the winter-meeting draft, faced the minimum 12 batters through the first four innings. He allowed one hit in that stretch, a second-inning leadoff single by Adam Dunn, who was erased in a double play.

Cincinnati scored in the sixth on consecutive doubles by pinch-hitter Brandon Phillips and Tony Womack. Felipe Lopez followed with a one-hopper that got past third baseman Joe Randa for a single, but Wilson hustled over from shortstop to retrieve the ball in foul territory and threw out Womack at the plate.

Lopez went to second and scored on Ken Griffey Jr.'s double off Damaso Marte, cutting Pittsburgh's lead to 3-2.

Pittsburgh added a pair of runs in the seventh off Matt Belisle on Chris Duffy's RBI double and Jason Bay's sacrifice fly. Griffey hit another RBI double in the eighth, off Mike Gonzalez.