This year’s top 5 are Rice Energy, New York City-based Alcoa, Fort Worth, Texas-based Range Resources, Eden Prairie, Supervalu and Mylan.
The Pittsburgh ketchup company's 2014 revenue of $10.9 billion was down slightly from $11.5 billion in 2013.
The rankings are based on market capitalization, a measure of the value that investors place on a public company.
The Top 10 included three Pittsburgh-based companies, one company based overseas, and one bank.
Return on equity, or ROE, is determined by dividing a company's net income by the average shareholder's equity.
Rice Energy of Canonsburg tops this year's ranking of firms based on revenue change, with Range Resources of Texas coming in second.
The New York-based communications giant and largest U.S. cell phone carrier leads on the net income list.
Newcomer Rice Energy is the only home-grown concern among the region's top-performing public companies.
The categories analyzed include revenue change, net income change, stock price change and return on equity.