Pitt lost its 35th consecutive Big East game Saturday, and with it its final chance to end the now two-year losing streak at home.
Playing in their final home Big East regular-season game before departing for the ACC next season, the Panthers fell to DePaul, 81-73.
Brianna Kiesel scored a career-high 28 points to lead Pitt, which kept the deficit in single digits for most of the game but couldn't get enough defensive stops down the stretch to challenge the Blue Demons. Asia Logan added 16 points and 12 rebounds -- her eighth double-double of the season.
DePaul outrebounded the Panthers, 48-40, led by 18 rebounds from forward Katherine Harry, who was also one of five Blue Demons to score in double figures. "It was just a tough game," Pitt coach Agnus Berenato said. "Rebounds hurt us."
Pitt will wrap up its regular season Monday at Rutgers. That will be the Panthers' last chance to end the losing streak which dates to Feb. 15, 2011.