Charles Manack connected with Jamie Fell on touchdown passes of 18, 40 and 3 yards to lead Frazier to a 21-14 upset of No. 4 Beth-Center in the Tri-County South Conference.
Manack completed 13 of 25 passes for 190 yards for the Commodores (5-2, 5-2), while Fell had six catches for 126 yards.
Cody Durant rushed for 154 yards and scored on runs of 68 and 24 yards for the Bulldogs (6-1, 6-1).
Chavas Rawlins completed 9 of 19 passes for 165 yards and one touchdown as the No. 3 Greyhounds (6-1, 6-1) beat the visiting Saints (5-2, 5-2). Rawlins connected with Javon Brown on the winning 35-yard scoring pass.
Justin Vickless ran for 206 yards and two touchdowns, and Chris Shortley threw for 136 yards and two touchdowns as the Spartans (4-3, 4-3) shut out the Cougars (1-6, 1-6) in the Black Hills Conference.
Lenny Williams threw four touchdown passes to lead the Vikings (6-1, 5-1) to a Big Seven Conference victory against the Golden Beavers (1-6, 0-6). Williams connected with Javelle Kirkland on two touchdowns, and with Brendan Blair and Wendell Miller on the other two.
Kaleb Susko tossed two touchdowns to Miles Williamson to lead the Buccaneers (3-4, 3-4) to a Black Hills Conference win against the host Trojans (1-6, 1-6).
Dan Barley scored on runs of 9, 7 and 34 yards to lead the Rangers (3-4, 3-4) to a win against the visiting Eagles (0-7, 0-7) in the Black Hills Conference.
Zachary Chandler hooked up with Ryan Welsh for touchdown passes of 9, 12 and 13 yards to lift host Avonworth (4-3, 4-2) past Springdale (4-3, 4-2) in the Eastern Conference. Chandler finished with 152 yards passing.
Dustin Conti ran for three touchdowns, while Jesse Jento and Nic Santoya each ran for two scores as the Rockets (5-2) beat the Royals (1-6) in a non-conference game.
Carmichaels (5-2, 4-2) handed host Avella (5-2, 4-2) its second consecutive loss in the Tri-County South.
Ernie Burkes threw one touchdown pass and ran for two more to pace the fifth-ranked Lancers (6-1, 6-1) in their Big Seven Conference win against Our Lady of the Sacred Heart (1-6, 1-6) at Robert Morris University.
Dante Marsick scored the first five touchdowns of the game to help No. 2 Rochester (7-0, 6-0) jump out to a 35-0 halftime lead on its way to a Big Seven Conference win at Laurel (4-3, 3-3). Marsick scored on runs of 1, 1, 44 and 62, and he caught an 82-yard touchdown reception from Ben Richko.
Five players scored for West Greene (3-4, 2-4) in its Tri-County South win against visiting Mapletown (3-4, 2-4).
The Bearcats (2-5, 1-5) blasted visiting Geibel Catholic (0-7, 0-6) in the Tri-County South.
Lonny Wells kicked a 19-yard field goal to cap a fourth-quarter rally and lead Apollo-Ridge (4-3, 4-2) to a surprising Eastern Conference win at Northgate (5-2, 5-1). Apollo-Ridge trailed 19-10 heading into the fourth quarter.