New cholesterol test is under debate

Doctors are divided over its usefulness

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WASHINGTON -- For heart health, you're supposed to know your numbers: Total cholesterol, the bad LDL kind and the good HDL kind. But your next checkup might add a new number to the mix.

More doctors are going beyond standard cholesterol counts, using another test to take a closer look at the bad fats -- a count of particles that carry LDL through the blood.

Cardiologists are divided over the usefulness of that approach. Proponents contend that it might help them spot at-risk patients that regular checks might miss, or get more information about how aggressively to treat them.

But so far, guidelines from major heart organizations don't recommend these extra tests. They're pricier than regular cholesterol exams, although Medicare and many other insurers pay for them. And it's not always clear what the results mean.

"I see a lot of people being confused," said Nieca Goldberg of New York University Langone Medical Center and the American Heart Association. Especially when they're used on lower-risk people, "you don't know how to make sense of the information," Dr. Goldberg said.

Yet up to half of patients diagnosed with heart disease apparently had normal levels of LDL cholesterol, and some doctors say particle testing might help find some of them sooner.

"For most people, the standard lipid profile is fine," said Michael Davidson of the University of Chicago. But "I get referred people who said, 'My cholesterol was fine. Why do I have heart disease?' We're showing them, well, because your particle number's sky high, and they were not aware that was a problem."

Dr. Davidson chaired a National Lipid Association committee that this month called the extra tests reasonable to assess which at-risk patients might need to start or intensify cholesterol treatment. That committee's meeting was paid for by a grant from eight pharmaceutical companies, including some makers of particle tests.

Cholesterol isn't the only factor behind heart disease. High blood pressure, smoking, obesity, diabetes or a strong family history of the disease can put someone in the high-risk category, even if their cholesterol isn't a red flag. Some doctors also are testing for inflammation in arteries that may play a role, too.

On the cholesterol front, doctors have long focused on three key numbers:

• Total cholesterol should be below 200.

• An LDL, or "bad" cholesterol, level below 130 is good for healthy people, but someone with heart disease or diabetes should aim for under 100.

• For HDL, the "good" cholesterol that helps control the bad kind, higher numbers are better -- 60 is protective, while below 40 is a risk.

Where do particles come in? Scientists have long known that small, dense LDL particles sneak into the artery wall to build up and narrow blood vessels more easily than larger, fluffier particles. While overall LDL levels usually correlate with the amount of particles in blood, they don't always -- just as a beach bucket of sand may weigh the same as a bucket of pebbles but contain more particles.

Only in recent years have commercial tests made particle checks more feasible -- although there's no standard method, and different tests measure in different ways. The tests add another $100 to $150 to regular cholesterol checks.

A study published last spring used one particle test, from Raleigh, N.C.-based LipoScience, to analyze a database of more than 5,000 middle-aged people whose heart health was tracked for five years. Most people's overall LDL and particle counts correlated pretty well. But people had a higher risk of heart disease when their particle count was much higher than their LDL predicted -- and, conversely, a lower risk if their particle count was lower than expected, said lead researcher David Goff Jr. of Wake Forest University.


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