Arizona Cardinals (4-0) at St. Louis Rams (2-2), 8:20 p.m., Thursday
The Skinny: The unbeaten Cardinals are the surprise team of the NFL, a turnaround that began last season when they won five of their final six games. Their defense, led by former Steelers assistant and Dick LeBeau-disciple Ray Horton, has been the difference. Keep an eye on the Rams, though. They've already matched last year's victory total, and they'll only get better with quarterback Sam Bradford. Plus, Jeff Fisher will continue to mold that defense.
Prediction: Cardinals, 23-20
Philadelphia Eagles (3-1) at Steelers (1-2), 1 p.m., Sunday
The Skinny: The Steelers have not lost the week following a bye since Mike Tomlin's first season. And they haven't lost back-to-back games since Week 13 of the 2009 season. The Eagles, are coming off a tough divisional victory against the Giants. And they can't score points (66).
Prediction: Steelers, 23-13
Miami Dolphins (1-3) at Cincinnati Bengals (3-1), 1 p.m., Sunday
The Skinny: Dolphins center Mike Pouncey, Maurkice's brother, has apologized to the Miami fans for the back-to-back overtime losses. He may want to draw up another apology when the Dolphins make it three losses in a row.
Prediction: Bengals, 30-20
Green Bay Packers (2-2) at Indianapolis Colts (1-2), 1 p.m., Sunday
The Skinny: Former Steelers offensive coordinator Bruce Arians takes over as interim coach in Indy while Chuck Pagano undergoes treatment for leukemia. Facing the Packers is not a good way to begin, unless the Pack gets another bad officials call against theM.
Prediction: Packers, 34-21
Baltimore Ravens (3-1) at Kansas City Chiefs (1-3), 1 p.m., Sunday
The Skinny: The Chiefs are starting to question whether they can win with Matt Cassel. Those questions will likely arise again after playing the Ravens, so long as Joe Flacco doesn't morph into those moments when he looks like, well, Matt Cassel.
Prediction: Ravens, 27-9
Cleveland Browns (0-4) at New York Giants (2-2), 1 p.m., Sunday
The Skinny: The Browns are the only winless team in the AFCL, but they have lost three games by 7 points or fewer. It might be a moral victory if they can keep it close against Eli Manning and the Giants, especially after their loss to the Eagles.
Prediction: Giants, 30-17
Atlanta Falcons (4-0) at Washington Redskins (2-2), 1 p.m., Sunday
The Skinny: Matt Ryan and Roddy White combined on an improbable 59-yard pass to pull out last week's last-second victory against Carolina. They might need similar heroics against RG3, the hottest thing to hit Washington since Alexander Ovechkin.
Prediction: Falcons, 24-23
Seattle Seahawks (2-2) at Carolina Panthers (1-3), 4:05 p.m., Sunday
The Skinny: Cam Newton's late fumble cost the Panthers an upset victory in Atlanta. It might be a different story against the Seahawks, who contemplated a QB change because of the offensive struggles. Imagine what would have happened if Golden Tate didn't shove Sam Shields in the back?
Prediction: Panthers, 21-13
Chicago Bears (3-1) at Jacksonville Jaguars (1-3), 4:05 p.m., Sunday
The Skinny: The Jaguars are the lowest scoring team in the NFL -- that might not get any better against the Bears, who had five interceptions Monday night against Tony Romo.
Prediction: Bears, 27-13
Denver Broncos (2-2) at New England Patriots (2-2), 4:25 p.m., Sunday
The Skinny: Another classic meeting between Peyton Manning and Tom Brady, though with a little different feel. Manning looked like his old self last week against the Raiders. The Patriots looked like their old self when they scored 45 points in the second half in Buffalo.
Prediction: Patriots, 27-17
Tennessee Titans (1-3) at Minnesota Vikings (3-1), 4:25 p.m., Sunday
The Skinny: Talk about your surprise teams? The Vikings have knocked off a pair of 2011 playoff teams -- the 49ers and Lions -- in the past two weeks. One more victory and they will eclipse last year's victory total. Goodness.
Prediction: Vikings, 24-21
Buffalo Bills (2-2) at San Francisco 49ers (3-1), 4:25 p.m., Sunday
The Skinny: The Bills might be glad to get out of the AFC East after allowing 100 points in two losses to division teams. But it won't get any easier against the 49ers, who rushed for 245 yards last week -- or 2 fewer yards than what the Patriots had against the Bills.
Prediction: 49ers, 34-13
San Diego Chargers (3-1) at New Orleans Saints (0-4), 8:20 p.m., Sunday
The Skinny: Can this slide continue for the Saints, who have lost direction without their head coach, Sean Payton? And can the Chargers, once a horrid road team, remain unbeaten away from San Diego (2-0)? A better question: Wonder how the Chargers feel now about letting Drew Brees go?
Prediction: Saints, 30-27
Houston Texans (4-0) at New York Jets (2-2), 8:30 p.m., Monday
The Skinny: The Jets allowed the Bills to rush for 195 yards and the 49ers to rush for 245. And, in the past seven quarters of the losses to the Steelers and 49ers, Mark Sanchez has completed 19 of 52 passes for 161 yards. That's 36.5 percent, in case you're wondering.
Prediction: Texans, 23-20