Pitt won its Big East opener today by beating Syracuse, 45-14, at the Carrier Dome.
Tino Sunseri threw for 266 yards and four touchdowns.
The Panthers (3-3, 1-0) scored on their first play from scrimmage en route to a 28-7 halftime lead.
Sunseri's first pass of the game to Devin Street went for a 79-yard touchdown to give the Panthers a 7-0 lead.
Syracuse tied the score in its next possession, but the Panthers scored the next 21 points in the half. Sunseri threw a 15-yard touchdown pass to Ray Graham with 23 seconds remaining in the first quarter. He threw a 30-yard strike to Mike Shanahan with 9:39 remaining in the second quarter.
Dion Lewis completed the first-half scoring with a 1-yard run with 3:18 to go before halftime.
Cornerback Ricky Gary put Pitt ahead, 35-7, when he returned an interception 80 yards for a touchdown early in the third quarter.
Dan Hutchins kicked a 24-yard field goal in the fourth quarter, and Brock DeCicco completed the scoring for Pitt when he caught a six-yard pass from Sunseri with 9:18 remaining.
Pitt will play host to Rutgers next Saturday at Heinz Field.